While this United side may not have accrued the Champions League nous of the Sir Alex Ferguson sides, they still have players such as Juan Mata and Antonio Valencia, who have played in the competition's finals.
And that's just how Jose Mourinho likes it. Now, attention turns to further progression in Europe and the Reds will be confident of maintaining our strong home form, having won all five games at Old Trafford in all competitions so far in 2018.
Vincenzo Montella does not have a lot of pressing injury concerns hampering his preparations for the crunch Champions League tie.
After what was viewed by many Manchester United fans as a disappointing result, Jose Mourinho's side laboured to a 0-0 draw at the Ramon Sanchez Pizjuan Stadium in Seville in the first leg.
Meanwhile Rashford is confident his development will not suffer from a lack of game time after scoring twice in a 2-1 victory against Liverpool on his return to the Manchester United starting line-up.
But United managed to down Liverpool without the France global on Saturday and have a number of their key players in good form, including Romelu Lukaku and Marcus Rashford. "And I remember him clearly in the meetings in the dressing room, at halftime, eating every word, listening to everything".
Sanchez has another four years on his deal beyond this season, so he will have plenty more chances to impress, even should United fall short this time around. The 35-year-old, from Willemstad, has already handled four Champions League matches this term - including games involving Liverpool, Chelsea and Celtic during the group stage.
"Right now, I'm probably not learning the most on the pitch", said the former academy graduate, who hopes to play a key role for England at the World Cup in Russian Federation. At 18, he was 5-foot-6 (1.70 meters) but, after a sudden growth spurt, he is 6-foot-4 (1.95m).
Against Liverpool, he formed an impenetrable midfield block with Nemamja Matic, helping United to keep its shape against Liverpool's fluid attack.
"There were some times there, two or three days, when I wondered whether I would carry on playing or not, is it worth it or not?"
Mourinho agrees and it will be fascinating to see how McTominay develops at United in the coming years.
Midfielder Michael Carrick will hope to be included after confirming on Monday that he will retire at the end of the season.
Yes, they have nearly certainly assured themselves of a second-place finish in the league.
He also praised the recent contributions of Scott McTominay, included in the Scotland squad for the first time, and Marcus Rashford: "I have to be honest and give the credit to the people of the Academy that was responsible for [Rashford's] formation".