The 29th professional contest between the pair will take place in the first match of Monday's night session.
In 2001 they were slated to meet in the Indian Wells semi-finals when Venus withdrew, handing Serena a walkover. There is obviously some rust for arguably the greatest to ever do it, but to win back-to-back matches without dropping a set is a fairly astounding feat for someone playing for the first time in 14 months.
The American who already has two Indian Wells title is vying to become the first woman to make it three here clinched her victory on the second match point when Bertens blasted a forehand as she broke the Dutch's serve six times.
Charlie Pasarell, then the tournament director, said in the same USA Today story that he didn't discount Richard Williams was racially abused.
Serena, unseeded in the wake of her long layoff, admitted she would have preferred not to come up against her sister so soon in the draw. But I call this a trial run, you know.
In 2004, Serena unveiled her own range of apparel under the label Aneres, her name spelled backwards, and it appears that she is now looking to expand the company with a range of cosmetics. In fact, it's the first time they've met before the Round of 16 since their very first head-to-head matchup more than 20 years ago.
"I still have a lot to give". She has won each of the last three matches and leads the series, 17-11. "When she's missing, it's not by much". There have been so many days, even still, that I'm like "how am I going to keep going"? There were moments literally when I'm in the hospital bed and I just think about that. I was always that girl that played with my dolls, and I went to fashion school, so it's not just made up for me. "So I think that's helping me out, too'".