All of Liverpool's prolific front 3 were on target as Sadio Mane and Roberto Firmino struck either side of Salah's deft header to take their combined tally for the season to 82. Guardiola's men arrived at Old Trafford with a handy eight-point lead over neighbours United at the summit.
A United victory on Sunday afternoon would keep City's champagne on ice for a few more days at least. "Normally United beats West Brom".
But the Spaniard believes leading City to the title would rank among his finest moments.
In addition, based on three points for a win, City's now tally is the most by any side after 33 games of an English top-flight campaign.
However, they now enjoy a 6-point cushion over Southampton thanks to a thrilling 3-2 win over Brighton at Selhurst Park with Wilfried Zaha scoring twice.
"It's one of the best by far".
The Citizens have splashed the cash left, right and centre, and that statement is no more true than when speaking about their defence, when Pep Guardiola has spent a nice round £50m on each of the right back, left back, and two central defenders in the last two years. He atoned with a 17th Premier League goal this season but missed another one-on-one having been ingeniously played through with a volleyed pass from Kevin De Bruyne. We handled pressure all season. Some pundits are already ranking City - who at one stage this season won a record 18 successive league games - alongside Manchester United's 1999 treble winners and the 2003-04 Arsenal "Invincibles".
"People say it was a big failure, what happened last week, but they don't understand the reality of football", Guardiola said.
"After that, in a competition like the Champions League, with decisions and good opponents happen in both games we can not complete closely against Liverpool but for the rest of the season, even the game against Wigan with 10 against 11 we were outstanding". The league is nine months. It's much more important what these players have done."The players have my total respect".
"The players have my total respect". Incredible. What they lived the other week was so unfair. "We did it.we nearly did it!" Ilkay Gundogan converted from the spot to double City's lead.
Most of their goals this season have come with a flourish, but for once City took a more direct approach.
A long ball from Kyle Walker saw Gabriel Jesus outpace Davinson Sanchez to race in on goal and finish coolly.
But - for all their possession - they could not muster any chances and it was City that had a golden opportunity to put the game to bed in the 64th minute.