Israel has faced worldwide criticism over its use of live fire but insists its actions are necessary to defend the border and stop mass infiltrations from the Palestinian enclave, which is run by the Islamist movement Hamas.
Senior Palestinian negotiator Saeb Erekat said: "The Guatemalan government has chosen to stand on the wrong side of history, to side with violations of global law and human rights, and to take a hostile step against the Palestinian people and the Arab world".
Organizers say the wave of border protests is meant in large part to break a decade-old blockade imposed by Israel and Egypt and pressure Israel to ease its restrictions.
The demonstrations were initially meant to end on May 15, but Hamas officials have said they want them to continue. "There are people who are storming the border attempting to kill Israeli soldiers, sending kites with incendiary devices". That's because, she said, Hamas lied to its own people claiming the Israeli soldiers had withdrawn and urging people to burst through the fence.
Hospitals in the Gaza Strip have been overstretched by the more than 2,700 people injured along Israel's border fence, including 1,300 by gunfire, United Nations agencies said in Geneva. No one was hurt by the gunfire.
"This was no peaceful protest", Israeli military spokesman Lt. Col. Jonathan Conricus wrote on Twitter.
A Palestinian security source in Gaza confirmed the target was a Hamas observation point, saying the Israeli attack resulted in no injuries.
Statements claiming that people recently killed in Gaza, including children, were terrorists, are outrageous, Russia's Acting Foreign Minister Sergey Lavrov said at a press conference on Wednesday.
Egyptian President Abdel Fattah al-Sisi said Egypt was in communication with both sides "so that this bloodshed would stop".
There were also several Israeli airstrikes on Hamas positions in Gaza.
"Rather, the violence comes from those who reject the existence of the state of Israel in any location".
There have been numerous calls for an independent investigation into the deaths, with Britain, Germany, Canada and Switzerland among those supporting such action.
President Donald Trump recognized Jerusalem as Israel's capital late a year ago, upending decades of USA policy in a move that was welcomed by Israeli Prime Minister Benjamin Netanyahu, but prompted the Palestinians to cut ties with the administration.
Israel has said its troops were defending its border and accused Hamas militants of trying to attack under the cover of the protest.
In statements prior to the meeting, Palestinian Ambassador in Cairo and Permanent Delegate to the Arab League Diab al Louh said the meeting should come up with decisions that are up to the unfolding events in the Palestinian territories.