Mrs Trump's lack of appearance at events she would normally be expected to attend has created headlines in the United States media and triggered conspiracy theories.
On May 14, Melania was hospitalized at Walter Reed National Military Medical Center for what her spokeswoman Stephanie Grisham said was "an embolization procedure to treat a benign kidney condition".
The first lady had recently launched her initiative to teach kindness to children.
President Donald Trump boarded the presidential helicopter on the South Lawn of the White House in the afternoon with his daughters Ivanka and Tiffany, his oldest son Donald Jr., and his son-in, law Jared Kushner.
However, many social media users were skeptical Melania Trump herself wrote that tweet.
As frenzied speculation began about Melania's quality of health and what she could possibly be doing, she took to Twitter on Wednesday to quell any untoward rumours.
Presidential officials said Melania, 48, would instead be staying at the White House in Washington DC this weekend.
Drawing a parallel between her tweet and POTUS' earlier tweet, social media went on a rollercoaster ride cracking jokes and framing unusual theories about the First Lady's tweet.
President Trump told Reuters Thursday that his wife is "in great shape" after her surgical procedure.
Everyone is asking where in the world the US First Lady, Melania Trump, is. However, Trump is apparently doing well, if her latest tweets are to be believed.
Former House Speaker John Boehner has a theory on why First Lady Melania Trump "doesn't look real happy every day".