Olivier Giroud will play former club Arsenal for the first time since moving to Chelsea.
Please note that all fixtures are subject to change for the purposes of television coverage or due to participation in European competition.
It is a similar story for neighbours United, who begin at home to Leicester.
Among the final round of matches, scheduled for May 12, Manchester City are at Brighton - where they started last season - while Cardiff and Wolves are at Manchester United and Liverpool respectively.
Absolutely, it is the game before the season starts.
The traditional Premier League 'Clasico' between Liverpool and United is due to be staged at Anfield on December 15, with the return taking place at Old Trafford on February 23.
Jose Mourinho will take his United side to Anfield and everyone will be hoping for more excitement than last year's 0-0 draw [barring a David De Gea wonder-save] provided.
Arsenal finished sixth and without a trophy, while Chelsea FC were fifth and won the FA Cup.
But when are the 10 biggest fixtures of the season taking place?
The Blues face a trip to Huddersfield as they look to regain their title, while Spurs will be travelling to Rafa Benitez's Newcastle to open their account.