It's an incredibly hard start for Unai Emery as the Gunners new chapter starts against a team tipped for more superiority after their exploits last season.
For so long some Gunners players have been regarded as snowflakes, shining during good times and melting under pressure.
Emery also insisted on Friday that Welbeck is not one of the players who would be free to leave before the European transfer window shuts at the end of the month.
Arsenal are an unknown quantity going into the new campaign, something which should excite and also intrigue fans. There was a lack of accountability in the team last season and the same players kept getting picked.
Three of his eight goals against the London outfit have come at the Emirates Stadium too, with three more at home and two on the hallowed turf of Wembley.
Although Emery might set his team up in a 4-2-3-1, we might see them switch toa 4-4-2 off the ball to counter City.
Unlike Arsenal, Guardiola's team are a force all over the pitch. Forget the World Cup and everything else, it's a new challenge. Benjamin Mendy is meanwhile fit again and will provide more consistency on the left.
While the rest of the league attempted to reload in order to give the Citizens a run for their money, Manchester City splashed plenty of cash of its own, signing winger Riyad Mahrez from Leicester City for a club-record $76.6 million.
The new Gunners boss begins life in the Premier League with a clash against the Citizens at the Emirates on Sunday afternoon. Midfielder Aaron Ramsey is a doubt for the fixture.
"Then, the contract is for speaking with the club and the players".
The German worldwide will likely start for the gunners in the defensive area.
Arsenal will be without Sead Kolasinac.
After all the pre-match hype, Danny Welbeck is not even in the Arsenal squad, let alone at left-back.