Lloris, who has endured a hard few weeks on a personal level after being fined £50,000 and receiving a 20-month driving ban following his pleading guilty to drink-driving, misses this weekend's game with a hamstring injury, while Alli suffered a knock during England's 2-1 defeat to Spain last weekend and misses out.
He picked up the problem during their 3-0 win over Manchester United in August.
Just as importantly for the home team, key midfielder Dele Alli is also expected to miss the match against the Reds, after picking up a hamstring injury with England.
He was fined £50,000 and banned from driving for 20 months.
"He is the first to regret about everything and all that happened is not good, he doesn't feel great", Pochettino said.
"I was surprised with the team selection - he played Dier on the right of a three in mid and he looked very uncomfortable", Shearer said on Match of the Day when asked about Pochettino's starting XI for the match. Of course all the women, men, people can make a mistake. "We need to give time to the players to get to their best and of course to show our potential in time".
Asked if the World Cup victor would remain as captain, Pochettino said: "Of course". "I made a mistake and now I need to pay".
The court was told the 31-year-old provided a sample containing 80 micrograms of alcohol per 100 millilitres of breath, more than twice the legal limit in England and Wales. "I take full responsibility for my actions, and it is not the example I wish to set". "It's a big point for him. I always want to go out onto the field to have fun and keep improving myself".
Liverpool, on the other hand, have the expectations of an entire city on their shoulders. I am happy with all the players. "It's not a moment to take risks now".
I think it is a situation that is under control I think but we respect all opinion and maybe some opinions are different to us.