Bill Hader collected the best comedy actor award for "Barry", a dark comedy about a hired killer who stumbles into an acting career.
"I'll be thanking you for the rest of my life for trusting me with your Midge", she said, referencing her character.
Saturday Night Live won, as expected, for variety sketch series, taking its lifetime Emmy total to a record-setting 72 wins.
Emmy hosts Michael Che and Colin Jost from "Saturday Night Live" sprinkled the evening with skits and jokes about diversity on television, sexual misconduct in the entertainment industry, and the power of streaming services like Amazon and Netflix. The networks, which air the Emmy telecast on a rotating basis, are so eager for the ad dollars it generates and its promotional value for fall shows that they endure online competitors sharing the stage.
The Emmys are back, with Game of Thrones, Westworld and The Handmaid's Tale leading the nominations ahead of the ceremony in Los Angeles today. NBC's "This Is Us" is the only network nominee in the category.
The Amazon television show about a 1950s housewife who turns to stand-up comedy won four Emmys in the first hours, including for Rachel Brosnahan's lead role as a 1950s housewife who turns to stand-up after a divorce.
Matthew Rhys took his first best drama actor Emmy for playing a conflicted Russian spy in the final season of the FX Cold War series 'The Americans'. FX hit show, Atlanta, which is created & starred in by Donald Glover, was up for "Lead Actor in a Comedy Series", but unfortunately Donald didn't win.
"I wrote this (speech) 43 years ago", said the former Happy Days actor, who had been nominated six times previously.
Oh played along from her seat: "Thank you, but it's an honor just to be Asian", said the Korean-Canadian actress. But I don't think there's any danger of that.
"You wonder why I don't want to call you my girlfriend?"
Supporting Actor, Comedy Series: Henry Winkler, "Barry".