We already knew that right-back Antonio Valencia would be left out amid concerns over how well his injury-prone knees would hold up on Young Boys' artificial pitch and summer signing Diogo Dalot makes his first appearance of the season in the club captain's absence. Do I feel if we have to go to play a big massive game am I going to start that game all the time?
Marcus Rashford's future has been a hot topic over the last few days, with Jose Mourinho defending his handling of the youngsters' development.
"Everybody knows he has a favourite surface, but he also has to win on other surfaces that he is not in love with, so we have to do it".
"We have to do it, but Antonio is the only one we need to protect with his clinical situation, apart from that we give everything and try to win".
United have won back-to-back Premier League games against Burnley and Watford following consecutive defeats to Brighton and Tottenham.
"These players have the quality to play on this surface, they have speed and great technique, so it won't be a problem for the great players they have". "They have shaped football at the highest level in recent years".
United go into the match in good spirits having recovered from a shaky start to the domestic season by winning their last two league matches.
Marouane Fellaini. The much-maligned midfielder played the full 90 minutes in both wins and he is proving to be the most effective, and perhaps most important, player in Mourinho's armoury.
"So, we have (Romelu) Lukaku, Rashford, (Juan) Mata, Alexis (Sanchez), (Anthony) Martial and they can not play all together".
"I think we are improving", Mourinho said after securing back-to-back Premier League victories.
The two-time Champions League victor believes football has evolved beyond the days of players being pigeon-holed in one position and Rashford's versatility is an added string to his bow.