Watch the new teaser trailer above.
Harry is now a Commonwealth Youth Ambassador and has already spoken about how his wife will join him in his work - which will see them begin a major Commonwealth tour in October.
She's even won the favour of Queen Elizabeth II and has been seen on more than one occasion giggling alongside the 92-year-old when they've attended royal engagements together.
The trailer features a moment where Prince Harry admits that he often "panics" when he bumps into his grandmother in the halls of Buckingham Palace.
In the brief clip, Markle can be seen admiringly stroking her silk tulle wedding veil hand-embroidered with the flora of each Commonwealth country and saying, "Fifty-three countries, oh my goodness".
It appears that the duchess' views are rubbing off on Prince Harry, who skipped the traditional 2018 Boxing Day shoot and Balmoral Castle grouse hunting last month, activities he had partaken in since he was a boy, reports Fox News.
Speaking to the new recruits he says: 'Have you bumped into the Queen yet?
It will be a two-part series, featuring behind-the-scenes footage with the Queen and other members of the Royal Family, including Prince Charles, Prince William, Prince Harry, Meghan Markle, Princess Anne, and the Countess of Wessex. Starting with next month's trip Down Under, am I right?!
"I know some have started eating - as you should, I'm the last one who'd want the food to get cold - so please enjoy a attractive lunch".
The first part of Queen Of The World will be screened on September 25 at 9.15pm on ITV.