If Bryant does play, Payton said he won't be moving around the formation right off the bat and he pointed to the red zone as an area where the former Cowboy might be able to make an impact for the Saints.
Bryant is likely to miss at least eight months, which would put him into a similar position he found himself in heading into 2018.
Soon after, Bryant tweeted a message of determination, writing that the injury "is the ultimate test".
According to National Football League reporter Tom Pelissero, Bryant was helped off the field at Saints practice on Friday and is undergoing an MRI to determine the extent of his injury.
Bryant was selected in the 1st round of the 2010 NFL Draft by the Dallas Cowboys and was selected to go to the Pro Bowl 3 different times. But news broke earlier this week that Dez agreed to a one-year contract with the New Orleans Saints.
Of course, Saints players weren't the only ones who reacted to the news.
That said, Payton said he hasn't seen Bryant practice yet and "we'll see" if Bryant plays this weekend after that changes.