"There has been a bomb threat phoned into the CNN offices in NY", tweeted the official CNN public relations account.
The network temporarily went to taped programming for about half hour before going live from the street while police investigated.
Police said a man with a southern accent called CNN about 10 p.m. Thursday and said five bombs had been placed throughout the facility inside the Time Warner building at Columbus Circle.
This isn't the first time the building has been the target of bomb threat phone calls.
Just two months ago, bombs were sent to the CNN, as well as top Democrats like Barack Obama and the Clintons.
CNN said several fire alarm bells signaling an evacuation rang inside its newsroom shortly after 10:30pm.
While none of the devices had actually detonated, the Federal Bureau of Investigation said that they were not dummies.
And network host Don Lemon tweeted that the offices were evacuated in the middle of his live show, which was taken off the air. "We grabbed what we could and got out of the building and now, we are standing outside of the building", Lemon told his viewers. It is unclear whether the threat was directed at CNN or another location close by. Earlier in the night, Trump had lambasted the "fake news media" on Twitter as well, falsely claiming that reporters don't mention the Republican midterm gains in the Senate.